Grapes

Grapes are berries. In fact, they are considered “true” berries. Red wine is made from black or purple grapes. Black grapes, not red, contain the most phytonutrients, including the flavonol resveratrol. The darker the skin, the more phytonutrients and health benefits.

Other important nutrients in grapes include potassium, copper, iron, and manganese, which also promote healthy bones and muscles. Manganese is a key nutrient that is needed for a health nervous

system, the formation of collagen, and to promote protein metabolism.

There are thousands of grape varieties. As you might suspect, the varieties used to make wine are the most researched. However, Concord grape juice has been used in several cancer studies. Most wine is made from the juice of Vitis vinifera grapes, which is the grape

species usually associated with Europe, but originated in Iran. Chardonnay and Cabernet Savignon are examples of Vitis vinifera wine grapes. Thompson and Red Globe are examples of Vitis vinifera table grapes. Perhaps the most cultivated American species, Vitis Rotundifolia) also includes both wine and table varieties. For example, Muscadine grapes are used for both table and wine. Another species popular in the U.S. is the species, Vitis Labrusca, witch includes Delaware and Concord table varieties.

While this information may not seem especially pertinent for our purposes, it is important to note that each variety, (not species) has its own nutritional profile. Most of the nutritional information you read online is derived from studies of wine varieties, not table varieties. Of the table varieties I have been able to document, the Muscadine variety seems to be the most nutritious. (1) However, all grapes share certain nutrients, they are simply in different quantities.

Antimicrobial

Red and black grapes are strong antimicrobials. Research has shown that they are effective against the herpes simplex virus. They are also a good choice when fighting bacterial infections, especially in the digestive system. They also contain high levels of the vitamins, A, C, and K. which boost your immune system and help prevent viral infections. (2) (3)

Cancer

Like the other berries, grapes are little balls of Mother Nature’s medicine. They contain two primary flavonoids that are active cancer fighters, resveratrol and quercetin. Both are strong antioxidants that help control the free radicals that stimulate cancer growth. Grape seeds contain a special group of flavonoids called proanthocyanidins. Grapes also contain many other phytonutrients that probably contribute to grape’s anticancer properties.

The phytonutrients in grapes also have anti-inflammatory properties. Since inflammation plays a role in the initiation of cancer tumors, grapes help prevent cancer.

As might be expected, cancer studies using grapes or grape-derived chemicals in human trials are few and far between. However, there have been a few such studies done on animals or in vitro, and there are new studies in progress. One in vitro and animal study done by Ram Prasad, Mudit Vaid, and Santosh K. Katiyar at the University of Alabama at Birmingham and published on the internet site, Plos One showed the Proanthocyanidins in grape seed inhibited cancer cell growth and caused natural apoptosis of pancreatic tumor cells. Other studies have shown grapes protect against esophageal, lung, mouth, pharynx, endometrial, prostate, and colon cancers. (5) (6)

Perhaps the most impressive cancer study using grapes tested the ability of concord grape juice to control breast cancer. Researchers found that the phytonutrients in the juice prevent aromatase from changing androgen to estrogen. Scientists believe excess estrogen is a major cause of breast cancer. Lab rats experienced major reduction in tumor size. (7)

Dementia

Another area of recent grape research is in the prevention and control of dementia, especially Alzheimer’s disease. In a 2011 study at Mount Sinai School of Medicine researchers found that grape seed polyphenolic extracts administered to mice substantially reduced neurotoxins known to promote Alzheimer’s disease. Another study done in India and published online by the National Center for Biotechnology Information in 2012 found that, “… learning and memory in STZ-group decreased significantly compared to Sham group. However, intake of red grape juice increased speed of learning and improvement of memory in Alzheimer’s rats.” (8)

Cardiovascular Benefits

Insufficient potassium intake is a common problem in America. The Institute of Medicine’s Food and Nutrition Board’s recommended daily intake is 4700 milligrams, but a research study published in The American Journal of Clinical Nutrition found that only 2 percent of Americans reached that level. One study found that a high potassium intake results in a twenty percent decrease in death from all causes.

The high concentrations of potassium in grapes promote heart health, help control blood pressure, and reduce the risk of stroke. Also, resveratrol and quercetin, the two flavonoids in grapes that are best known, help the liver remove toxins from the blood and reduce platelet clumping.

The antioxidant properties of grapes help prevent platlet buildup in the arteries and help regulate blood pressure. Pterostilbene, a close relative of resveratrol helps balance cholesterol levels by promoting healthy vessels and arteries. (9)

Additional Health Benefits of Grapes

The potassium in grapes also helps maintain the chemicals that promote nerve impulse transmission and muscle contraction. protects against loss of muscle mass and bone density, and helps to prevent kidney stones.

The antioxidant flavonoids in grapes have anti-aging properties that prevent macular degeneration and cataracts. They also help reduce wrinkles.

References

(1) Joseph C. Brown, Guohui Huang, Vivian Haley-Zitlin and Xiuping Jiang, Antibacterial Effects of Grape Extracts on Helicobacter pylori Applied and Environmental Microbiology, August 2015, Volume 81, Issue 15.

(2) Nada El Darra, Joanna Tannous, Paulette Bou Mouncef, James Palge, Joseph Yaghi, Eugène Vorobiev, Nicolas Louka, Richard G. Maroun A Comparative Study on Antiradical and Antimicrobial Properties of Red Grapes Extracts Obtained from Different Vitis vinifera VarietiesBiochemistry Unit and Research and Analysis Center, Faculty of Sciences, Saint-Joseph University of Beirut, Beirut, Lebanon. Food and Nutrition Sciences, 2012, 3, 1420-1432.

(3) J Konowalchuk, J I Speirs Virus inactivation by grapes and wines. Appl Environ Microbiol. 1976 December; 32(6): 757–763. PMCID: PMC170457.

(4) Mudit Vaid, Tripti Singh, Santosh K. Katiyar Grape Seed Proanthocyanidins Inhibit Melanoma Cell Invasiveness by Reduction of PGE2 Synthesis and Reversal of Epithelial-to-Mesenchymal Transition Plos One, Published: June 27, 2011DOI: 10.1371/journal.pone.0021539.

(5) Prasad R, Vaid M, Katiyar SK. Grape proanthocyanidin inhibit pancreatic cancer cell growth in vitro and in vivo through induction of apoptosis and by targeting the PI3K/Akt pathway. PLoS One. 2012;7(8):e43064. doi: 10.1371/journal.pone.0043064. Epub 2012 Aug 8.

(6) Manjinder Kaur, Chapla Agarwal, Rajesh AgarwalNutr.Anticancer and Cancer Chemopreventive Potential of Grape Seed Extract and Other Grape-Based Products. The Journal of Nutrition, 2009 Sep; 139(9): 1806S–1812S.doi: 10.3945/jn.109.106864 PMCID: PMC2728696.

(7) Zhou K1, Raffoul JJ. <ahref=”http: www.ncbi.nlm.nih.gov=”” pubmed=”” 22919383″=”” target=”_blank”>Potential anticancer properties of grape antioxidants. J Oncol. 2012;2012:803294. doi: 10.1155/2012/803294. Epub 2012 Aug 7.

(8) Zahra Siahmard, Hojjatollah Alaei, Parham Reisi, and Ali Asghar Pilehvarian The effect of red grape juice on Alzheimer’s disease in rats dv Biomed Res. 2012; 1: 63. Published online 2012 Aug 28. doi: 10.4103/2277-9175.100188. PMCID: PMC3544087

(9) Mustali M. Dohadwala and Joseph A. Vita Grapes and Cardiovascular Disease J Nutr. 2009 Sep; 139(9): 1788S–1793S. doi: 10.3945/jn.109.107474 PMCID: PMC2728695 </ahref=”http:>